Qualifications | Biography | Current Appointment | Previous appointments |National Organisations | International Organisations

Postgraduate Education | Editorial Boards | Examiner | Advisory Board | Medical Journal Referee | Society Membership

Management Experience | Ethics Courses | Sabatical Leave | Visiting Consultant | Charity Work | Clinical Research | Publications

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QUALIFICATIONS:

MB.BS 1970
MRCS.LRCP 1970
MRCP (UK) Paeds 1973
FRCP (London) 1989
FRCPCH 1997

GMC Number:

1460438

MDU Number

090963D

BIOGRAPHY:

With more than thirty five years of clinical experience of working with children with kidney disease I am one of the most senior and experienced paediatricians and paediatric nephrologists, nationally and internationally. Having been appointed as a Consultant in 1983 I was responsible for establishing the Paediatric Nephrology Department at The Royal Free Hospital and for developing the first renal transplant programme in North London for children over the age of five years. Within three years I had established a dialysis and renal transplant programme for children aged between one and five years old at Great Ormond Street Hospital (GOSH). Subsequently, for logistic reasons the two units were sited together at GOSH and the largest centre for dialysis and renal transplantation for children in the United Kingdom was opened in 1986.

As lead clinician in nephrology for ten years between 1990 and 2000, I witnessed the reputation of the renal unit at GOSH grow to become one of the largest and most active departments for treating children of all ages and with all types of renal disease in Europe and North America. In the past twenty five years more than 650 children have had successful renal transplants. The overall success rate has been improving dramatically over this time with patient survival almost 100 percent and graft survival improving with each decade reflecting the better medical care given to children and growing experience with modern immunosuppression. I have been the principal investigator at GOSH for three major international randomised clinical trials of immunosupression in children receiving renal transplants. These trials are unique in the world literature.

Reflecting my interest for transplantation in children I have been an active member of the International Pediatric Transplant Association and am a Past President of this society dedicated to the care of children and their families who are in need of solid organ and bone marrow transplantation. It is a privilege to have been elected to this prestigious position by my colleagues.

My special interests within paediatric nephrology are not limited to transplantation. I have dedicated much time to the clinical and laboratory research of children with glomerular disease particularly nephrotic syndrome. I set up the only special out- patient clinic for children with this condition in the UK in order to study demography and epidemiology, and have recently received grant funding to establish a similar clinic for young adults. Working together with adult colleagues in nephrology will be an innovation. I am also the recipient of a major National Institute Of Health Research grant awarded to investigate the preferred induction treatment corticosteroid regimen for children presenting with nephrotic syndrome for the first time.

As a paediatrician my goal is to represent the interests of children and child health care and as a Past President of The Royal Society of Medicine, Section for Paediatric and Child Health and during my presidential year was responsible for organising a series of educational courses designed to engage with and update both general paediatricians and trainees.

Additional areas with which have been involved, include medical management and clinical ethics. I was Clinical Director of the medical unit at GOSH for ten years with responsibility for enlarging the number of specialities within the directorate. Similarly as Clinical Director of the International and Private Patient Directorate I was involved with the planning for the new Private Patient wing at GOSH and the need to offer child care services to a much wider community both within the UK and overseas.

As Chairman of one of the first UK Clinical Ethics Committees I was able to promote the subject to a wide medical and non-medical audience. As result a Department of Clinical Ethics has been established at GOSH. I have served as a trustee of the UK Clinical Ethics Network and have been a member of the Ethics Committee of The British Transplantation Society and The European Renal Association. Currently I am a member of the Ethics Committee of the Transplantation Society.

My extensive clinical practice and peer reviewed publications reflect my experience in caring for infants and children with congenital, hereditary and acquired renal disease. I have published in excess of 100 original peer reviewed contributions, book chapters and reviews. I teach and lecture regularly to post graduate students in the UK and overseas. I lecture overseas regularly and am a visiting paediatric nephrologist to many institutions.

In 2010 I received funding in order to establish a Transition Clinic for 16 – 25 year old patients who suffer with nephrotic syndrome. This specialist clinic for young people is the first of its kind in the UK and is based in the UCL Centre for Nephrology, Royal Free Hospital Campus.

I continue to have an active paediatric clinical practice in the UK and work closely with colleagues in paediatric urology, transplant surgery, radiology and histopathology reflecting the diverse nature of the speciality and the need to have the close support of key clinicians and laboratory based specialities.


 

CURRENT APPOINTMENTS:

Emeritus Consultant Paediatrician & Paediatric Nephrologist
International Patient Centre
Great Ormond Street Hospital for Children NHS Trust
Great Ormond Street
London WC1N3JH

Honorary Reader in Paediatric Nephrology
Institute of Child Health
University College
London

Honorary Consultant Nephrologist (Sessional. Appointed 2010)
UCL Centre for Nephrology
The Royal Free Hospital
Pond Street
London NW3 2QG

PREVIOUS APPOINTMENTS:

Pre-Registration
1970-1971 House Surgeon, Guy's Hospital, House Physician, St Mary Abbots Hospital

Senior House Officer
1971-1974 Royal Free Hospital. Renal Unit; Guy's Hospital, Paediatrics; The London Hospital, Paediatrics; John Radcliffe Hospital, Neonatal; Great Ormond Street, Paediatrics.

Registrar
1975-1977 Great Ormond Street Hospital & Queen Elizabeth Hospital.

Research Fellow
1977-1978 Department of Immunology, Institute of Child Health

Hon. Senior Registrar
1979-1983 Lecturer in Paediatrics, Guy's Hospital Medical School

Senior Lecturer & Consultant
1983-1989 Senior Lecturer in Paediatrics, Royal Free Hospital School of Medicine; Consultant Paediatric Nephrologist,
Royal Free Hospital

Consultant Paediatrician & Paediatric Nephrologist
1989-2009 Great Ormond Street Hospital for Children NHS Trust, Honorary Reader in Paediatric Nephrology, Institute of Child Health, Senior Clinical Lecturer, Institute of Urology & Nephrology, University College London.

NATIONAL ORGANISATIONS

Royal College of Physicians Standing Committee of Members

Member 1976 - 1979

British Paediatric Association Council

Junior Staff Representative 1982 -1983

Conference of Medical Academic Representatives

Clinical Representative 1982 - 1983

Inner London Education Authority, Royal Free Hospital School

Governor 1985 - 1989

University of London, Board of Studies in Medicine

Member 1986 - 1989

Renal Association, Executive Committee

Member 1989 - 1993

Association of Paediatricians of North Thames (East)

Secretary 1995 - 1997

British Medical Association

Local Negotiating Committee - Great Ormond Street Hospital for Children NHS Trust
Chairman 1996 - 1997

Royal College of Paediatrics & Child Health

i. Finance Committee 1998 - 2002
ii.Clinical Director’s Sub-Committee -  Member 1998 - 2002
iii.Membership Panel 1999

British Transplantation Society

Ethics Committee 2002 - 2006

Royal Society of Medicine, Paediatric Section

Council Member 2005 -
President 2008 - 2009

British Association for Paediatric Nephrology

Treasurer 2006 - 2009

United Kingdom Clinical Ethics Network

Board of Trustees; Committee Member 2006 - 2008

Association of Medical Registered Charities  2012 -
Trustee

INTERNATIONAL ORGANISATIONS

International Paediatric Transplant Association

Past President 2013 - 2015
President 2011 - 2013
President Elect 2009 - 2011
Secretary/Treasurer 2007 - 2009
Education Committee. Co-Chair 2004 - 2007
Councillor 2005 - 2007

European Renal Association

Ethics Committee 2010 – 2015

POST GRADUATE EDUCATION

Seminars and meetings held at:

The Institute of Child Health London

Advances in Paediatric Nephrology 1990 – 2001

Paediatric Nephrology and Urology, Continuing Education Programme
Co-Organiser – Annual Meeting 2001 – 2007

Nephrology for the General Paediatrician
Regular Contributor 2000 – 2006

MSc Course for Paediatricians
Regular Contributor 2000 - 2009

International Paediatric Transplant Association

Co-Chairman Education Committee 2004 – 2007

Fundamentals of Paediatric Transplantation
Course Organiser – Innsbruck, Austria 2005

Fundamentals of Paediatric Transplant Immunology
Course Organiser – Cancun, Mexico 2007

Scientific Advisory Committee Chair
6th Congress on Pediatric Transplantation
Montreal, Canada 2011

EDITORIAL BOARDS

Pediatric Transplantation. Elected 2000 - 2010

UK Clinical Ethics Network. Elected 2003 - 2008

Pediatric Nephrology
Section Editor – Transplantation. Elected 2004

EXAMINER

University of London – MB Final 1983 – 1995

Royal College of Physicians  - MRCP 1996 – 2000

Royal College of Paediatrics and Child Health – MRCPCH 2000 – 2004

RCPCH – Senior Examiner 2004 – 2009

ADVISORY BOARD

Novartis Pharmaceuticals UK Ltd (Transplantation) 2000 – 2006

MEDICAL JOURNAL REFEREE

Archives of Disease in Childhood, Lancet, European Journal of Paediatrics, Nephrology Dialysis and Transplantation, British Journal of Radiology, Bone Marrow Transplantation.

OTHER

Editor – Guy’s Hospital Gazette 1969 – 1970

Festschrift Programme Organiser and Chairman for Professor Martin Barratt CBE 1997

SOCIETY MEMBERSHIP

British Medical Association

British Association for Paediatric Nephrology

European Society for Paediatric Nephrology

The Renal Association

European Renal Association

International Paediatric Nephrology Association

International Paediatric Transplantation Association

International Society of Nephrology

British Transplantation Society

The Worshipful Society of Apothecaries of London
Livery Committee Member 2001 - 2004                                                                      

Freeman of the City of London

Royal Society of Medicine:  Paediatrics & Child Health Section

Medico- Legal Society

Independent Doctors Federation

Young Persons Health Speciality Interest Group

The Transplantation Society

 

MANAGEMENT

ROYAL FREE HOSPITAL AND SCHOOL OF MEDICINE 1984-1989

Academic Staff Association
Member 1984-1987

School Council
Member 1986-1987

Education Council
Member 1984-1989

Library Committee
Member 1986-1989

Hampstead Health Authority, Division of Child Health
Member1984
Chairman 1988-1989

Hampstead Health Authority, Medical Executive Committee
Member 1988-1989

Hampstead Health Authority, Division of Physicians
Member 1984-1989


GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS TRUST

Medical Unit/Urology Directorate
Clinical Director 1990-1997

Department of Nephrology
Lead Clinician 1990-1999

International and Private Patient Directorate
Clinical Director 1997-2002

Clinical Ethics Forum
Member 1995-1999

Clinical Ethics Committee
Chairman 2000-2005 
Member  2000-2008

NATIONAL

NHS Kidney Care
Evaluation of Models and Approaches to Supporting Young Adults with Kidney Disease
Advisor to Matrix Knowledge Group 2010-2012 

MANAGEMENT COURSES ATTENDED

Management Course (Special Health Authorities)
Kings Fund  1992

Information Needs for Clinical Directors
Sharpening The Focus
Front-line Management for Consultants
British Association of Medical Managers  1994

Taking Tough Decisions
British Association of Medical Managers 1994

Approaches to Medical Management
BHK Consultancy  1995

Medical Managers:  Challenges & Solution
BMA/British Association of Medical Managers 1996

Top Manager Programme
Kings Fund 1999

Institute of Healthcare Management: Medicine for Managers 2000
(Invited speaker: specialised renal services – managing the
interface between secondary and tertiary services)

The NHS Confederation
Workshop: Consultants as Leaders for Care Improvement 2001

ETHICS COURSES/SYMPOSIA ATTENDED

Difficult Decisions:  Ethics support in the delivery of Healthcare 2001
BMJ/Nuffield Trust/Ethox

Approaches to Medical Ethics 2002
Ethox

UK Clinical Ethics Network 2002
ICH London (Convener)
Guest Lecture:  Caring for children.  Professor Sir Ian Kennedy

UK Clinical Ethics Network  2008
Annual Conference: Value of Life – Value of Death
Sheffield

Pediatric Deceased Donation 2014

Transplantation Society Meeting

Geneva

 

SABBATICAL LEAVE

February – April 2002

Objectives: 

Review of the molecular genetics of congenital nephrotic syndrome

Completion of research studies on nephrotic syndrome

Review of function of Clinical Ethics Committee

VISITING CONSULTANT PAEDIATRIC NEPHROLOGIST

Mubarak Hospital
Kuwait 1989, 1994, 1998

Al Jazeira Hospital, Abu Dhabi
United Arab Emirates 1989, 1995, 1996, 1999, 2000

American Hospital, Dubai
United Arab Emirates 2002

St. Luke’s Hospital
Malta 1995-2007

Mater Dei Hospital
Malta  2008-2009

Hamad General Hospital,
Qatar 1996

Gentofte Hospital
University of Copenhagen
Denmark  2003

Roskilde Hospital
Denmark 2005, 2007, 2009

Dubai National Hospital
Dubai 2005

Al Qassimi Hospital, Sharjah
United Arab Emirates 2010

CHARITY  WORK

Trustee of Kids Kidney Research: Appointed 2002
Chairman of Trustees  2008

Trustee of Transplant Games and Recreational Fund (GOSH) 2002 - 2008

Advisory Committee – Tuberous Sclerosis Association. Appointed 2005

Norwood Children and Families Trust  - Council Member. Appointed 2007

Royal Medical Benevolent Fund – Medical Liaison Officer.  Appointed 2010 - 2015

Trustee of Association of Medical Registered Charities. Appointed 2012

 

CLINICAL RESEARCH

RENAL TRANSPLANTATION - GRANTS AWARDED

A. CLINICAL TRIALS

RANDOMISED CLINICAL TRIAL
FUJISAWA.  £23K. (1996 – 1999)
Randomised trial of tacrolimus v. Cyclosporin microemulsion in renal transplantation. 

RANDOMISED CLINICAL TRIAL
FUJISAWA.  £60K.  (2001 – 2003)
An open, multicentre, randomized, parallel-group study to compare the efficacy and safety of tacrolimus/azathioprine/steroid triple regimen with and without the induction of the monoclonal antibody basiliximab in children after kidney transplantation.  

RANDOMISED CLINICAL TRIAL
ASTELLAS. £25K. (2005 – 2007)
A multicentre, randomised, open, clinical study to compare the safety and efficacy of a combination therapy of Tacrolimus, Mycophenolate Mofetil (MMF) and Daclizumab with early steroid withdrawal versus Tacrolimus, MMF and steroids in children after kidney transplantation.

B. PHARMOKINTETIC STUDY

PHARMACOKINETICS
NOVARTIS.  £32K.  (2001 – 2002)
A study of the pharmacokinetics of Neoral in paediatric de-novo renal transplantation.

C. LONG TERM FOLLOW UP STUDY

LONG TERM FOLLOW UP OF CHILDREN POST RENAL TRANSPLANTATION (1973-2003)
NOVARTIS £5k (2004).
Royal Free and Great Ormond Street Hospital

NEPHROTIC SYNDROME – GRANTS AWARDED

LONG-TERM TAPERING VERSUS STANDARD PREDNISOLONE THERAPY FOR INITIAL EPISODE OF NEPHROTIC SYNDROME. NATIONAL NATIONAL MULTICENTRE RANDOMISED DOUBLE BLIND TRIAL.

PREDNOS 1
l
Pilot Study: National Kidney Research Fund £50K and Kidney Research Aid Fund £50K (2004 – 2008)
Definitive Study: NETSCC Health Technology Assessment £850k (2010 – 2015)

SHORT COURSE DAILY PREDNISOLONE THERAPY AT THE TIME OF UPPER RESPIRATORY TRACT INFECTION IN CHILDREN WITH RELAPSING STEROID SENSITIVE NEPHROTIC SYNDROME

PREDNOS 2

NIHR £800k (2012 – 2014)

TO ESTABLISH A TRANSITIONAL CLINIC FOR YOUNG ADULTS WITH NEPHROTIC
SYNDROME AND OTHER FROMS OF GLOMERULAR DISEASE AT THE ROYAL FREE
HOSPITAL
Garfield Weston Foundation & Kids Kidney Research £213k (2010 – 2012)

TO INVESTIGATE THE MOLECULAR GENETICS OF STEROID RESPONSIVE NEPHROTIC SYNDROME: UCLH/ROYAL FREE HOSPITAL
Kids Kidney Research, Equipment Grant £ 100K (2011)

MEDICO LEGAL

I have received instruction for expert opinion regularly since 1990. My specialism is restricted to the kidneys and urinary tract to include congenital and acquired disorders affecting all ages of infants, children and young adults.

Cases on which I have been asked to provide expert opinion include;

Urinary tract infection
Structural abnormalities of the kidney and urinary tract
Neuropathic Bladder
Acute kidney failure
Neonatal acute kidney failure
Acute glomerulonephritis
Metabolic disease of the kidney
Nephrotic Syndrome
Kidney Biopsy
Hypertension
Chronic Kidney Disease
Dialysis
Kidney Transplantation

The number of instructions received  is approximately 25 per annum and invariably will require meeting with Counsel. The majority of legal work undertaken is on behalf of the plaintiff and it is rare for cases to require a Court Hearing.

My professional qualifications  are listed in both the Expert Witness Directory and the UK Register of Expert Witnesses.

PUBLICATIONS

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